The analysis was based on observed-cases population of the 380 patients who continued in the extension phase. Use Cosopt exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Use chloramphenicol as directed by your doctor. Check the label on the medicine for exact dosing instructions. Xalatan may cause a gradual change in the color of your eyes or eyelids and lashes, as well as increased growth or thickness of your eyelashes. These color changes, usually an increase in brown pigment, occur slowly and you may not notice them for months or years. Color changes may be permanent even after your treatment ends, and may occur only in the eye being treated. This could result in a cosmetic difference in eye or eyelash color from one eye to the other.
Educating people with glaucoma is essential for medical treatment to be successful. The person who understands the chronic long-term potentially progressive nature of glaucoma is more likely to comply with medical treatment. Tilt your head back, look upward, and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and place one drop into the pouch. Look downward and gently close your eyes for 1 to 2 minutes. Place one finger at the corner of your eye near the nose and apply gentle pressure. This will prevent the medication from draining out. Try not to blink and do not rub your eye. Repeat these steps for your other eye if so directed.
If Latisse gets directly in your eyes, rinse with water. United States and its territories. Indications, uses and warnings on Drugs. Wait at least 10 minutes before using any other eye drops your doctor has prescribed. Read the Patient Information that comes with Bimatoprost Ophthalmic Solution before you start using it and each time you get a refill. There may be new information. This leaflet does not take the place of talking with your physician about your treatment.
Store away from light and moisture. Keep all medicines away from children and pets. The pigmentation change is due to increased melanin content in the melanocytes rather than to an increase in the number of melanocytes. After discontinuation of latanoprost, pigmentation of the iris is likely to be permanent, while pigmentation of the periorbital tissue and eyelash changes have been reported to be reversible in some patients. Patients who receive treatment should be informed of the possibility of increased pigmentation. Increased pigmentation of iris develops slowly; may not be evident until after several months to years of bimatoprost therapy. 1 Long-term effects of these changes are unknown. 1 Patients should be examined regularly; therapy may be discontinued if increased pigmentation persists.
Although some studies have reported a significantly higher average intraocular pressure in women than in men, other studies have not shown any difference between men and women. DROP-TAINER is a registered trademark of Alcon Research, Ltd. Repeat for the opposite upper eyelid margin using a new sterile applicator. This helps minimize any potential for contamination from one eyelid to another. Bimatoprost was not mutagenic or clastogenic in the Ames test, in the mouse lymphoma test, or in the in vivo mouse micronucleus tests. Latanoprost has been reported to cause changes to pigmented tissues. The most frequently reported changes have been increased pigmentation of the iris, periorbital tissue eyelid and eyelashes. Pigmentation is expected to increase as long as latanoprost is administered. Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Lumigan. These medications may be counterfeit and potentially unsafe. If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy. Ask your health care provider for advice if you are unsure about the online purchase of any medication. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. Chloramphenicol may reduce the number of clot-forming cells platelets in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor. This information should not be used to decide whether or not to take chloramphenicol or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about chloramphenicol. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to chloramphenicol. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using chloramphenicol. Do not exceed the recommended dose or use chloramphenicol for longer than prescribed without checking with your doctor. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Latisse only for the indication prescribed. Azopt drops are to be used only by the patient for whom it is prescribed. Do not share it with other people. If you develop an infection or injury, or have surgery, check with your doctor about the continued use of your current bottle of bimatoprost. You may be advised to start using a new bottle.
Place one drop on the disposable sterile applicator supplied with the package and apply evenly along the skin of the upper eyelid margin at the base of the eyelashes. The upper lid margin in the area of lash growth should feel lightly moist without runoff. Blot any excess solution runoff outside the upper eyelid margin with a tissue or other absorbent cloth. Dispose of the applicator after one use. Repeat for the opposite eyelid margin using a new sterile applicator. What other drugs will affect Latisse? At doses at least 41 times the maximum intended human exposure, the gestation length was reduced in the dams, the incidence of dead fetuses, late resorptions, peri- and postnatal pup mortality was increased, and pup body weights were reduced. It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding. Some MEDICINES MAY INTERACT with cyanocobalamin b12. Use latanoprost drops in the evening unless your doctor tells you otherwise. When the eye drop form of this medication is applied directly into the eyes to treat glaucoma, it may slowly over months to years cause brown discoloration of the colored portion of the eye iris. This form of bimatoprost used to improve eyelash appearance could also have this effect. Also, this medication may cause eyelid changes or a darkening of the skin around the base of the eyelashes. After stopping use, eyelid skin darkening should go away after several weeks to months. However other side effects such as discoloration of the iris may be permanent. Tell your doctor if any of these side effects occur. An may show a glaucoma-damaged optic nerve. What are the ingredients in Bimatoprost Ophthalmic Solution? Abnormal taste; bloodshot eyes; blurred vision; dizziness; drowsiness; dry eyes; feeling that something is in your eye; headache; increased tear production; minor burning, itching, or stinging of the eye; nausea. Shake well before each use. Bimatoprost ophthalmic may also be used for purposes not listed in this medication guide. Depending on the amount of optic nerve damage and the level of intraocular pressure control, people with ocular hypertension may need to be seen from every 2 months to yearly, even sooner if the pressures are not being adequately controlled. Irvine, CA; 2002 May. Solutions: Over time, your hair may return to its pre-chemo texture. But the first hair that grows back is especially fragile. Avoid chemical processes like coloring or straightening for a while. And it's not just the early hair that's prone to damage. The on your scalp may be sensitive for 6 months or more after treatment. You may open the delayed-release capsule and sprinkle the medicine into a spoonful of applesauce to make swallowing easier. Swallow the mixture right away without chewing. Do not save for later use. lotriderm
What other drugs will affect bimatoprost ophthalmic Lumigan? In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Patients with thin corneas may be at a higher risk for glaucoma development; therefore, your ophthalmologist may use a measuring device, called a pachymeter, to determine your corneal thickness. This will prevent the from draining out. Try not to blink or rub your eye. Some medical conditions may interact with cyanocobalamin b12. Caution is advised with night driving and when hazardous activities are undertaken in poor illumination. Use only the number of drops your doctor has prescribed. If you use more than one drop, wait about 5 minutes between drops. F and protect from freezing. How should I use Restasis? This medication has been prescribed for your current condition only. Do not use it for another condition unless told to do so by your doctor. Eyelash changes are likely reversible upon discontinuation of treatment. buy bimatoprost online nz bimatoprost
Use this medication regularly in order to get the most benefit from it. Remember to use it at the same time each day. It is important to continue using bimatoprost even if you feel well. Most people with or high pressure in the eye do not have symptoms. Atropine drops may cause harm if it is swallowed. If you may have taken it by mouth, contact your or emergency room right away. Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Discard any opened, unused bottles after this time period. Bimatoprost is a structural prostaglandin analog. Although the precise mechanism of action is unknown the growth of eyelashes is believed to occur by increasing the percent of hairs in, and the duration of the anagen or growth phase. This medicine may be harmful if swallowed. No information is available on overdosage in humans. Prescription treatments are sometimes prescribed for conditions that are not mentioned in patient information leaflets. Do not use Bimatoprost Ophthalmic Solution for a condition for which it was not prescribed. Do not give Bimatoprost Ophthalmic Solution to other people. It may not be appropriate for them to use. Latanoprost drops may cause your eyelids to darken. It may also cause changes in the way that your eyelashes grow eg, length, thickness, number of lashes. These effects usually go away after you stop using latanoprost drops. Discuss any questions or concerns with your doctor. Inform patients of the possibility of hair growth occurring outside of the target treatment area if Bimatoprost Ophthalmic Solution repeatedly touches the same area of skin outside the treatment area. Keep this product, as well as syringes and needles, out of the reach of children. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal. It is not likely that other drugs you take orally or inject will have an effect on topically applied bimatoprost. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products. How should I use Cosopt? Use this medication regularly in order to get the most benefit from it. Remember to use it at the same time each day. It is important to continue using latanoprost even if you feel well. Most people with or high pressure in the eye do not feel sick. Bimatoprost Ophthalmic Solution is intended for use on the skin of the upper eyelid margins at the base of the eyelashes. Refer to Illustration 2 below. DO NOT APPLY to the lower eyelid.
Azopt drops may be harmful if swallowed. Certain medicines, including antibiotics, methotrexate, or pyrimethamine, may interfere with lab tests for vitamin B 12 and folic acid. Be sure your doctor and lab personnel know all the medicines that you are taking. Advise patients about the potential for increased brown pigmentation of the iris, which may be permanent. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; difficulty urinating; dry mouth; eye pain; fever; flushing or dryness of the skin; irregular or rapid heartbeat; unsteadiness on your feet. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; depression; difficulty breathing; eye irritation, swelling, pain, or discharge; eyelid pain, redness, scaling, drooping, crusting, or swelling; fainting; fast, slow, or irregular heartbeat; fever, chills, or persistent sore throat; sensitivity to light; severe or persistent feeling that something is in your eye; severe or persistent headache or dizziness; shortness of breath; vision changes. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Cosopt only for the indication prescribed. Krauss AHP, Chen J, Woodward DF. The pharmacology of AGN 192024 Lumigan a novel ocular hypotensive agent. Abstract presented at Third International Glaucoma Symposium. Prague, Czech Republic: 2001 Mar 21-5. CHILDREN younger than 2 years old; safety and effectiveness in these children have not been confirmed. If your medicine comes with a special cap, follow the directions on how to use this properly. Do not use this medication while wearing contact lenses. Latisse may contain a preservative that can discolor soft contact lenses. Wait at least 15 minutes after using this medicine before putting in your contact lenses. The pigmentation change is due to increased melanin content in the melanocytes rather than to an increase in the number of melanocytes. The long term effects of increased pigmentation are not known. Iris color changes seen with administration of Bimatoprost Ophthalmic Solution may not be noticeable for several months to years. Typically, the brown pigmentation around the pupil spreads concentrically towards the periphery of the iris and the entire iris or parts of the iris become more brownish. Neither nevi nor freckles of the iris appear to be affected by treatment. Treatment with Bimatoprost Ophthalmic Solution can be continued in patients who develop noticeably increased iris pigmentation. rden.info tinidazole
Patients with mean baseline IOP of 24-25 mmHg who were treated for 6 months in multi-center, randomized, controlled trials demonstrated 6-8 mmHg reductions in IOP. General Information about Bimatoprost Ophthalmic Solution. Bimatoprost Ophthalmic Solution may interfere with the desired reduction in IOP. Patients using prostaglandin analogs for IOP reduction should only use Bimatoprost Ophthalmic Solution after consulting with their physician. Some medical conditions may interact with chloramphenicol. African-Americans with ocular hypertension were 5 times more likely to develop glaucoma than whites. Findings suggest that, on average, African-Americans have thinner corneas, which may account for this increased likelihood to develop glaucoma, as a thinner may cause pressure measurements in the office to be falsely low. Bimatoprost Ophthalmic Solution was evaluated for its effect on overall eyelash prominence in a multicenter, double-masked, randomized, vehicle-controlled, parallel study including 278 adult patients for four months of treatment. The primary efficacy endpoint in this study was an increase in overall eyelash prominence as measured by at least a 1-grade increase on the 4-point Global Eyelash Assessment GEA scale, from baseline to the end of the treatment period week 16. Bimatoprost Ophthalmic Solution was more effective than vehicle as measured by the GEA score, with statistically significant differences seen at 8-week, 12-week, and 16-week primary endpoint treatment durations. Bimatoprost ophthalmic solution has been reported to cause changes to pigmented tissues. The most frequently reported changes have been increased pigmentation of the iris, periorbital tissue eyelid and eyelashes. Pigmentation is expected to increase as long as bimatoprost is administered. The pigmentation change is due to increased melanin content in the melanocytes rather than to an increase in the number of melanocytes. After discontinuation of bimatoprost, pigmentation of the iris is likely to be permanent, while pigmentation of the periorbital tissue and eyelash changes have been reported to be reversible in some patients. Patients who receive treatment should be informed of the possibility of increased pigmentation. The long term effects of increased pigmentation are not known. Systemic toxicity following topical ocular administration of pilocarpine is rare, but occasionally patients who are sensitive may develop sweating and gastrointestinal overactivity following the suggested dosage and administration. Overdosage can produce sweating, salivation, nausea, tremors and slowing of the pulse and a decrease in blood pressure. In moderate overdosage, spontaneous recovery is to be expected and is aided by intravenous fluids to compensate for dehydration. For patients demonstrating severe poisoning, atropine, the pharmacologic antagonist to pilocarpine, should be used. Do not use Cosopt while you are wearing contact lenses. This medication may contain a preservative that can be absorbed by soft contact lenses. It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Pilocarpine Hydrochloride Ophthalmic Solution is administered to a nursing woman. Take this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness; chest, jaw, or arm pain; confusion; difficult or painful urination; eye irritation, swelling, pain, or discharge; eyelid pain, redness, scaling, drooping, or swelling; fainting; fast, slow, or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; one-sided weakness; pain, numbness, weakness, or tingling of an arm or leg; red, swollen, blistered, or peeling skin; severe or persistent headache or dizziness; shortness of breath; slurred speech; sudden, unexplained weight gain; sudden, unusual sweating; swelling of the hands, ankles, or feet; symptoms of liver problems eg, dark urine, loss of appetite, pale stools, severe stomach pain, yellowing of the skin or eyes; unusual tiredness or weakness; very cold or blue fingers and toes; vision changes eg, double vision, loss of vision; wheezing. Studies estimate that 3-6 million people in the United States alone, including 4%-10% of the population older than 40 years, have intraocular pressures of 21 mm Hg or higher, without detectable signs of glaucomatous damage using current tests. Cantor LB. Bimatoprost: a member of a new class of agents, the prostamides, for glaucoma management. Expert Opin Investig Drugs. No. There is currently no therapeutically equivalent version of Lumigan available in the United States. geodon price help
FDA pregnancy category C. It is not known whether bimatoprost ophthalmic will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. If you miss a dose of chloramphenicol, use it as soon as possible. Then use your doses at evenly spaced times as directed by your doctor. Do not use 2 doses at once. Also, just like a water balloon can burst if too much water is put into it, the optic nerve in the eye can be damaged by too high of a pressure. See Images 1-2. Each mL of Latanoprost Ophthalmic Solution contains 50 micrograms of latanoprost. Known hypersensitivity to bimatoprost or any ingredient in the formulation. Check the label on the medicine for exact dosing instructions. Tilt your head back. Using your index finger, pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close your eyes. Immediately use your finger to apply pressure to the inside corner of the eyelid for 1 to 2 minutes. Do not blink. Remove excess medicine around your eye with a clean, dry tissue, being careful not to touch your eye. Wash your hands to remove any medicine that may be on them. What is hypotrichosis of the eyelashes? REM sleep when microinjected into the formation. Do not rinse the dropper. Replace the dropper cap after each use, and keep the cap tightly closed.
Lowering high pressure inside the helps to prevent blindness. Use cyanocobalamin b12 as directed by your doctor. Check the label on the medicine for exact dosing instructions. If you have a history of any severe allergic reaction, talk with your doctor. You may be at risk for an even more severe allergic reaction if you come into contact with the substance that caused your allergy. This medicine has been prescribed for you only. If your intraocular pressure is 28 mm Hg or higher, you are treated with medicines. After 1 month of taking the drug, you have a follow-up visit with your ophthalmologist to see if the medicine is lowering the pressure and there are no side effects. If the drug is working, then follow-up visits are scheduled every 3-4 months. famous oxybutynin
If any of these effects persist or worsen, notify your doctor or pharmacist promptly. This technique involves the use of a special contact lens to examine the drainage angles or channels in your to see if they are open, narrowed, or closed. Bimatoprost reduces pressure in the eye by increasing the amount of fluid that drains from the eye. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; chest pain or discomfort; confusion; eye irritation, swelling, pain, or discharge; eyelid pain, redness, scaling, drooping, or swelling; fainting; mental or mood changes; one-sided weakness; pain, numbness, weakness, or tingling of an arm or leg; severe or persistent headache or dizziness; shortness of breath; slow or irregular heartbeat; slurred speech; sudden unusual weight gain; swelling of the hands, ankles, or feet; very cold or blue fingers or toes; vision changes; wheezing. Bimatoprost Ophthalmic Solution is a prescription treatment for hypotrichosis used to grow eyelashes, making them longer, thicker and darker. Visual field testing checks your peripheral or side vision, typically by using an automated visual field machine. This test is done to rule out any visual field defects due to glaucoma. Visual field testing may need to be repeated. If there is a low risk of glaucomatous damage, then the test may be performed only once a year. If there is a high risk of glaucomatous damage, then the test may be performed as frequently as every 2 months. Hg or more may suggest glaucoma. Early primary open-angle glaucoma is very likely if the intraocular pressure is steadily increasing. Timolol and brimonidine can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine. Soft contact lenses may absorb a chemical in latanoprost drops. Remove contact lenses before you use latanoprost drops; lenses may be placed back in the eyes 15 minutes after use of latanoprost drops. During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. Do not use Xalatan while wearing contact lenses. This medication may contain a preservative that can discolor soft contact lenses. brand arcoxia rezeptfrei
If you have any questions about atropine drops, please talk with your doctor, pharmacist, or other health care provider. If you have any questions about latanoprost drops, please talk with your doctor, pharmacist, or other health care provider. Do not give this medication to a child younger than 1 year old without the advice of a doctor. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. This medication is used to treat patients with not enough or inadequate eyelashes. Bimatoprost makes the eyelashes more noticeable by causing more eyelashes to grow and making them longer, thicker, and darker. Bimatoprost is similar to a natural chemical in the body prostaglandin.
To apply drops, first. To avoid contamination, do not touch the dropper tip or let it touch your or any other surface. Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal. Close your eyes for 2 or 3 minutes with your head tipped down, without blinking or squinting. Gently press your finger to the inside corner of the eye for about 1 minute, to keep the liquid from draining into your tear duct. To determine other possible causes for your high eye pressure, an ophthalmologist a medical doctor who specializes in and surgery assesses whether your drainage system called the "angle" is open or closed. Do not crush, chew, or break an enteric coated pill, or a Prilosec OTC tablet. Swallow the pill whole. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; eye pain or itching; irritated eyelids. If you use more than one drop in the same eye, wait about 5 minutes before putting in the next drop. What should I avoid while using bimatoprost ophthalmic Lumigan? Some MEDICINES MAY INTERACT with latanoprost drops. However, no specific interactions with latanoprost drops are known at this time. Using this medicine with other drugs that make you sleepy or slow your breathing can increase these effects. Ask your doctor before using Combigan with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures. Lab tests, including eye exams, may be performed while you use brimonidine. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. CHILDREN; they may be more sensitive to its effects, especially drowsiness. The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Store Alphagan P eye drops at room temperature away from moisture and heat. Do not freeze. Keep the bottle tightly closed when not in use. More than 1 eye medicine may be used to lower eye pressure. If you use other medicines in your eye, wait at least 5 minutes between using brimonidine and your other eye medicines. If a drop misses your eye, try again. betamethasone cost walmart canada
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F for 6 weeks. Heartburn is often confused with the first symptoms of a heart attack. Seek emergency medical attention if you have chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, and a general ill feeling. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Always consult your doctor or healthcare specialist for medical advice. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. cipro
The optic nerve appears normal. To avoid contamination, do not touch the dropper tip or let it touch your eyelashes or any other surface. Do not rinse the dropper. Replace the dropper cap after each use, and keep the cap tightly closed. To apply this medication, first wash your hands and face. Remove any makeup and contact lenses. Contact lenses may be reinserted 15 minutes after applying this medication. Place one drop of this medication onto the provided applicator. Then right away draw the applicator carefully across the skin of the upper eyelid margin at the bottom of the eyelashes going from the inner part of your lash line to the outer part. Blot any excess solution that is applied beyond the eyelid margin. Throw away the applicator after applying the medication. Repeat with a new applicator for the other upper eyelid. This medication is not for use on the lower eyelids.
Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye with the tip down. Look up and away from the dropper as you squeeze out a drop, then close your eye. Storage: Protect from light. The following information is based on clinical trial results from a multicenter, double-masked, randomized, vehicle-controlled, parallel study including 278 adult patients for four months of treatment. If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Steady-state blood levels were achieved during the first week of dosing.
Reference Listed Drug RLD is an approved drug product to which new generic versions are compared to show that they are bioequivalent. A drug company seeking approval to market a generic equivalent must refer to the Reference Listed Drug in its Abbreviated New Drug Application ANDA. By designating a single reference listed drug as the standard to which all generic versions must be shown to be bioequivalent, FDA hopes to avoid possible significant variations among generic drugs and their brand name counterpart. Store Combigan eye drops at room temperature away from moisture and heat. Do not freeze. Keep the bottle tightly closed when not in use.